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Mississippi faces a profound substance use crisis compounded by systemic poverty, rural isolation, limited healthcare access, and deeply entrenched stigma. While the state has long struggled with alcohol and methamphetamine use, recent years have seen a dramatic rise in opioid-related overdose deaths, particularly due to fentanyl.
According to the Mississippi State Department of Health, opioid overdose fatalities have increased sharply, with synthetic opioids now involved in the vast majority of drug-related deaths across the state. Urban areas like Jackson and Gulfport offer some inpatient and outpatient treatment options, including detox services and MAT (medication-assisted treatment) programs.
However, in many rural counties—especially in the Delta and along the Mississippi River—there is a significant shortage of licensed providers, mental health professionals, and addiction specialists. Many residents in these areas must travel hours for basic care or rely on underfunded community health centers and church-based recovery programs that lack clinical oversight.
Mississippi has not expanded Medicaid, leaving tens of thousands of low-income residents without coverage for substance use disorder treatment. Even those who do qualify under current eligibility often face limited provider networks and out-of-pocket costs that create barriers to care.
Stigma remains a powerful deterrent, particularly in conservative and religious communities where addiction is still widely viewed as a personal failure rather than a public health issue.
Harm reduction infrastructure is extremely limited; while naloxone is available through some public health offices and pharmacies, syringe service programs and fentanyl test strips are virtually nonexistent or face legal and political opposition.
Faith-based recovery programs are prevalent and often deeply trusted in small communities, but they may not offer evidence-based therapies or integrated mental health care. Telehealth has helped bridge access gaps in some rural areas, especially for MAT maintenance and counseling, but internet access remains a serious challenge for many households.
Mississippi’s youth face growing risks related to vaping, alcohol, and marijuana, while older adults often contend with untreated pain and long-term prescription dependencies. The state has begun to pilot drug courts and diversion programs aimed at redirecting nonviolent offenders into treatment, but these are limited in scope and heavily dependent on county-level support.
Mississippi’s Native American communities, such as the Mississippi Band of Choctaw Indians, face additional access challenges, including under-resourced tribal health systems and geographic isolation. Workforce shortages across the behavioral health field further strain the system, making it difficult to expand services even where funding exists.
Addressing addiction in Mississippi will require a multifaceted strategy—one that includes Medicaid expansion, workforce development, infrastructure investment, and a cultural shift toward viewing substance use as a medical issue deserving of compassion and long-term care..
 | A Bridge To RecoveryA Bridge To Recovery in Jackson, MS, is dedicated to providing comprehensive addiction services for individuals facing substance use disorders. The center offers a range of treatment options, including detoxification, residential care, outpatient programs, and aftercare support. With a focus on personalized care, A Bridge To Recovery creates a supportive environment that empowers clients to confront their challenges and rebuild their lives. The experienced team utilizes evidence-based practices to ensure a holistic approach to healing, addressing the physical, emotional, and spiritual aspects of recovery. Discover the transformative journey that awaits at A Bridge To Recovery. 1437 Old Square Rd Suite 101, Jackson, MS 39211 | Levels of Care:outpatient Payment Options:Private Insurance Self-Pay Options |  | |
 | Alcohol Services CenterAlcohol Services Center in Jackson, MS, is dedicated to providing specialized treatment for individuals struggling with alcohol addiction. Offering a range of services including assessment, detoxification, counseling, and aftercare support, the center focuses on creating personalized treatment plans that cater to each client\\\'s unique needs. With a compassionate and knowledgeable team, Alcohol Services Center fosters a supportive environment that promotes healing and recovery. Utilizing evidence-based practices, the center empowers clients to confront their challenges and build a foundation for lasting sobriety. Discover the path to recovery at Alcohol Services Center. 950 North West Street Jackson, MS 39202 | Levels of Care:Inpatientoutpatient Payment Options:Self-Pay Options | ||
 | Alliance Health CenterAlliance Health Center in Meridian, MS, offers comprehensive addiction treatment services for individuals facing substance use disorders. The center provides a variety of programs, including detoxification, residential treatment, outpatient services, and aftercare support. With a focus on personalized care, Alliance Health Center aims to address the unique needs of each client in a supportive and nurturing environment. The experienced team utilizes evidence-based therapies and holistic approaches to empower individuals on their journey to recovery. Discover how Alliance Health Center can help you reclaim your life and achieve lasting sobriety. 5000 MS-39, Meridian, MS 39301 | Levels of Care:DetoxInpatientoutpatient Payment Options:Medicaid Private insurance Self-Pay Options Financial Aid Medicare Military Insurance | ||
 | ALTRALTR in Jackson, MS, provides innovative addiction recovery services designed to support individuals battling substance use disorders. With a focus on personalized care, ALTR offers a range of programs, including detoxification, outpatient treatment, and aftercare support. The dedicated team of professionals utilizes evidence-based practices and holistic approaches to create a nurturing environment that fosters healing and personal growth. ALTR is committed to empowering clients on their path to recovery, equipping them with the tools needed for lasting sobriety. Explore the transformative services available at ALTR. 500 East Woodrow Wilson Drive, Suite D, Jackson, MS 39216 | Levels of Care:Detoxoutpatient Payment Options:Self-Pay Options | ||
 | Arms of MercyArms of Mercy in Greenville, MS, is dedicated to providing compassionate addiction recovery services for individuals facing substance use disorders. The center offers a range of programs, including detoxification, residential treatment, outpatient services, and life skills training, all designed to support clients on their journey to recovery. With a focus on holistic care, Arms of Mercy addresses the physical, emotional, and spiritual aspects of healing, creating a nurturing environment that fosters personal growth. The experienced team is committed to empowering individuals to reclaim their lives and achieve lasting sobriety. Discover the supportive community at Arms of Mercy. 1341 Beauchamp Rd, Greenville, MS 38703 | Levels of Care:outpatient Payment Options:Free | ||
 | Baptist Behavioral HealthBaptist Behavioral Health in Columbus, MS, offers comprehensive mental health and addiction treatment services tailored to meet the needs of individuals struggling with substance use disorders and mental health challenges. The facility provides a range of programs, including inpatient and outpatient treatment, counseling, and support services designed to promote healing and recovery. With a team of experienced professionals, Baptist Behavioral Health focuses on personalized care, utilizing evidence-based practices to empower clients on their journey to wellness. Discover a welcoming environment that prioritizes your mental health and recovery at Baptist Behavioral Health. 2520 5th St N, Columbus, MS 39705 | Levels of Care:Inpatientoutpatient Payment Options:Medicaid Private insurance Self-Pay Options Medicare Military Insurance | ||
 | Baptist Memorial Hospital Chemical Dependency UnitThe Baptist Memorial Hospital Chemical Dependency Unit in Columbus, MS, offers specialized treatment for individuals struggling with substance use disorders. Focused on providing a safe and supportive environment, the unit features comprehensive programs that include detoxification, inpatient care, and outpatient services. The experienced team of healthcare professionals is committed to delivering personalized treatment plans tailored to the unique needs of each patient. Utilizing evidence-based therapies and holistic approaches, Baptist Memorial Hospital aims to empower individuals on their journey to recovery and long-term sobriety. Experience compassionate care at the Chemical Dependency Unit. 2520 5th St N, Columbus, MS 39705 | Levels of Care:Inpatient Payment Options:Medicaid Private insurance Self-Pay Options Financial Aid Medicare Military Insurance | ||
Barkley Hugh AllenBarkley Hugh Allen | ||||
Best of Both Worlds – Women’s Addiction CenterBest of Both Worlds – Women’s Addiction Center 8378 Ham Road, Meridian, MS 39305 | ||||
Bibleway Ministries12924 Seaman Rd. Ocean Springs, MS 39565 | ||||
Bradley A Sanders Adolescent ComplexBradley A Sanders Adolescent Complex | Payment Options:Medicaid | |||
Brighter Days IIBrighter Days II | Payment Options:Medicaid | |||
Buried Treasures HomeP.O. Box 720672 Byram, MS 39272 | Payment Options:Self-pay options Medicaid Financing available Medicare | |||
CARES CenterCARES Center | Payment Options:Medicaid | |||
Catholic CharitiesCatholic Charities | Payment Options:Self-pay options | |||
Catholic Charities - Hope HavenCatholic Charities - Hope Haven | Payment Options:Medicaid | |||
Center for Independent Learning - The Friendship ConnectionCenter for Independent Learning - The Friendship Connection | Payment Options:Self-pay options | |||
Central Mississippi Medical Center - Behavioral HealthCentral Mississippi Medical Center - Behavioral Health | Payment Options:Medicaid | |||
Central Mississippi Residential CenterCentral Mississippi Residential Center | Payment Options:Medicaid | |||
Christian Changes CounselingChristian Changes Counseling | Payment Options:Self-pay options |
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